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SCI Article

UPF1/SMG7-dependent microRNA-mediated gene regulation
성명 남진우()
소속 자연과학대학 생명과학과
캠퍼스
우수선정주 2019년 09월 5째주
Author Park, Jungyun (Grad Sch Biomed Sci & Engn); Ahn, Narae (Grad Sch Biomed Sci & Engn); Hwang, Jungwook (Grad Sch Biomed Sci & Engn); Seo, Jwa-Won (Dept Life Sci); Park, Seokju (Dept Life Sci); 남진우 (Dept Life Sci); 황정욱 (Dept Med Genet); Nam, Jin-Wu (Res Ins
Corresponding Author Info Hwang, J (reprint author), Hanyang Univ, Grad Sch Biomed Sci & Engn, Seoul, South Korea.; Nam, JW (reprint author), Hanyang Univ, Dept Life Sci, Coll Nat Sci, Seoul, South Korea.; Hwang, J (reprint author), Hanyang Univ, Dept Med Genet, Coll Med, Seoul, S
E-mail 이메일 아이콘jwnam@hanyang.ac.kr
Document Type Article
Source NATURE COMMUNICATIONS Volume:10 Issue: Pages:- Published:2019
Times Cited 0
External Information http://dx.doi.org/10.1038/s41467-019-12123-7
Abstract The stability and quality of metazoan mRNAs are under microRNA (miRNA)-mediated and nonsense-mediated control. Although UPF1, a core mediator of nonsense-mediated mRNA decay (NMD), mediates the decay of target mRNA in a 3'UTR-length-dependent manner, the detailed mechanism remains unclear. Here, we suggest that 3'UTR-length-dependent mRNA decay is not mediated by nonsense mRNAs but rather by miRNAs that downregulate target mRNAs via Ago-associated UPF1/SMG7. Global analyses of mRNAs in response to UPF1 RNA interference in miRNA-deficient cells reveal that 3'UTR-length-dependent mRNA decay by UPF1 requires canonical miRNA targeting. The destabilization of miRNA targets is accomplished by the combination of Agog and UPF1/SMG7, which may recruit the CCR4-NOT deadenylase complex. Indeed, loss of the SMG7-deadenylase complex interaction increases the levels of transcripts regulated by UPF1-SMG7. This UPF1/SMG7-dependent miRNA-mediated mRNA decay pathway may enable miRNA targeting to become more predictable and expand the miRNA-mRNA regulatory network.
Web of Science Categories Multidisciplinary Sciences
Funding National Research Foundation of Korea (NRF) - Korean Government [2017M3A9C8028794, 2017M3A9G8084539, 2018R1A2B2003782]; Medical Research Center - NRF of Korea of the Ministry of Science and ICT, Republic of Korea [2017R1A5A2015395]
Language English
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